It’s the second collab between the EDM star and rock group.
Rock in Rio will celebrate its 30th anniversary this year with a show in Las Vegas. Sam Smith, Charli XCX, Jessie J and Bleachers have been added to the lineup.
The dual-weekend festival will separate artists by genre, with rock acts playing May 8-9, followed by pop acts May 15-16.
Comic-Con International has never been known to be a music festival in even the loosest of terms, but recent years point towards that distinction changing.
Adele joins other artists like Whitney Houston, the Backstreet Boys and N’Sync who have reached the milestone.